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بالرغم من أن مؤسسة الغذاء والدواء إلى الآن لم توافق على استخدام حبوب سيلدينافيل للنساء لعلاج المشاكل الجنسية، إلا أنه ومن الاستخدامات غير المصرح بها للسيلدينافيل هي علاج انخفاض الرغبة الجنسية لدى المرأة.
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وجود عوامل تزيد من خطر الإصابة بالانتصاب المستمر، مثل فقر الدم المنجلي، الورم النخاعي المتعدد، وسرطان الدم.